High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN).However, direct causes of CIN, such as mutations in DNA replication and mitosis genes, are rare in HGSOC.We therefore asked whether oncogenic mutations that are common in H
Thermo-mechanical characterization and numerical modeling of lightweight mortars incorporating natural Pozzolan and expanded clay
This research studies the thermo-mechanical properties of lightweight mortars (LWM) based on natural pozzolan (NP) from the Moroccan Middle Atlas, which is a porous volcanic rock formed by rapid cooling during explosive eruptions, and expanded clay aggregates (EC).The purpose is to find optimal mortar mixtures Clothing Accessories for better therma
Pedagogy and architecture in educational spaces
The projects selected in this review aim to illustrate the relationship between pedagogy and architecture in contemporary experiences across the Alpine territory.The buildings, located in France, Switzerland, Austria, and Italy, showcase Push Button Switch an evolving relationship between traditional learning spaces and hybrid, multifunctional envi
High frequency of M. leprae DNA detection in asymptomatic household contacts
Abstract Background Characterization of the Mycobacterium leprae genome has made possible the development of Polymerase Chain Reaction (PCR) systems that can amplify different genomic regions.Increased reliability and technical efficiency of quantitative PCR (qPCR) makes it a promising tool for early diagnosis of leprosy.Index cases that are multib